Different Signaling Pathways Control Acute Induction versus Long-Term Repression of LHβ Transcription by GnRH
نویسندگان
چکیده
منابع مشابه
Different signaling pathways control acute induction versus long-term repression of LHbeta transcription by GnRH.
GnRH regulates pituitary gonadotropin gene expression through GnRH receptor activation of the protein kinase C (PKC) and calcium signaling cascades. The pulsatile pattern of GnRH release is crucial for induction of LHbeta-subunit (LHbeta) gene expression; however, continuous prolonged GnRH exposure leads to repression of LHbeta gene transcription. Although in part, long-term repression may be d...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2002
ISSN: 0013-7227,1945-7170
DOI: 10.1210/en.2001-211215